Although there is limited data on the role of the circadian clock in OSA (von Allmen et al., 2018; Yang et al., 2019; Gabryelska et al., 2020), it may play a significant role in this disease (Entzian et al., 1996; Smith et al., 2017; Butler et al., 2015). This evidence concerns the gene CLOCK and obstructive sleep apnea syndrome.