A large number of literature reports indicated that there was a deterministic relation between higher CRP level, change in brain structure, and depression (D'Mello & Swain, 2017; Felger et al., 2020; Kelly et al., 2019; Ng et al., 2018; Vulser et al., 2015), still the relationship between peripheral inflammation, brain structure, and depression remains unclear. This evidence concerns the gene CRP and major depressive disorder.