A recent work showed that DNA methylation of CRP was significantly associated with reduced global gray matter/cortical volume and widespread reductions in integrity of 16/24 white matter tracts, the methylation‐based measures showed stronger associations with imaging metrics than serum‐based CRP measures, and these findings provide evidence for central effects of peripheral inflammation from both serological and epigenetic markers of inflammation, including in brain regions previously implicated in depression (Green et al., 2020). Here, CRP is linked to depressive disorder.