Four profiles were identified: ‘healthy (H) < tumour-adjacent (TA) < tumour (T), for CIN, GGI, MYC, proliferation and wound response; ‘H < TA = T’ for E2F3; ‘H = TA < T’ for 38-GES, 70-GES, glycolysis, IRGS and PNI; ‘H > TA > T’ for TGFβ (Figure 1 and Supplementary Table S3). Here, E2F3 is linked to neoplasm.