CCN1 and atherosclerosis: Among the 58 genes down-regulated by Cezanne inhibition (Supplementary material online, Figure S4A), the extracellular matrix-associated signalling protein CCN1 caught our attention due to its reported cellular functions in VSMC senescence,37 proliferation,38 migration,39 and adhesion,40 and its potential implications in neointima formation,24,38,41 arteriosclerotic intimal hyperplasia,42 as well as atherosclerosis.43