Among the proteins, the levels of GSTP1, CRP and TNC were reduced in the AH samples from the POAG combined with cataract group, the GDF11 level was increased in the POAG combined with cataract group, and no significant differences in PLOD1 and TGF‐ß levels were observed between the two groups. Here, PLOD1 is linked to open-angle glaucoma.