CDK6 is required for the maintenance and development of MLL‐rearranged AML,14 and overexpression of CDK6 partially rescued bort‐mediated anti‐leukemogenesis, indicating that CDK6 plays an essential role in the bort‐mediated anti‐leukemogenesis activity. The gene discussed is KMT2A; the disease is acute myeloid leukemia.