Inactivation of core HR genes (eg, BRCA1/2) or HR associated genes (PTEN, CHEK2, SPOP, CHD1) and impairment of NHEJ pathways by BCL2 overexpression and TMPRSS2‐ERG fusion have been well described in PCa,185 and PARP inhibition can result in synthetic lethality by preventing not only base excision repair but alternative end joining pathways when both HR and NHEJ pathways are compromised. The gene discussed is SPOP; the disease is posterior cortical atrophy.