A PCa cell line derived from AA men called “E006AA” had increased tumorgenicity in the presence of fibroblasts from AA men, and proinflammatory paracrine mediators (BDNF, CHI3L1, DPPIV, FGF7, IL18BP, IL6, and VEGF) were all increased in AA derived fibroblasts. The gene discussed is IL18BP; the disease is posterior cortical atrophy.