A PCa cell line derived from AA men called “E006AA” had increased tumorgenicity in the presence of fibroblasts from AA men, and proinflammatory paracrine mediators (BDNF, CHI3L1, DPPIV, FGF7, IL18BP, IL6, and VEGF) were all increased in AA derived fibroblasts. This evidence concerns the gene CHI3L1 and posterior cortical atrophy.