It is thought to be involved in the development of castration resistance metastasis (although clinically antibody to IL6 was unsuccessful as a therapeutic option for this patient group), the regulation of cellular stemness by STAT3 phosphorylation, resistance to the non‐steroidal anti‐androgen enzalutamide, as well as demonstrating anti‐apoptotic effects and so potentiating PCa cellular survival. This evidence concerns the gene IL6 and posterior cortical atrophy.