AR and obesity due to melanocortin 4 receptor deficiency: IL6 specifically correlates with high‐risk Gleason scores and AR signaling (via STAT3, MAPK kinase, and PI‐3 kinase/AKT pathways),225, 227, 228, 229 and PI‐3 Kinase/AKT pathway signaling is also upregulated in diabetes, obesity, and hypertension,230 which itself can upregulate AR signaling in PCa.225, 231, 232