IL6 specifically correlates with high‐risk Gleason scores and AR signaling (via STAT3, MAPK kinase, and PI‐3 kinase/AKT pathways),225, 227, 228, 229 and PI‐3 Kinase/AKT pathway signaling is also upregulated in diabetes, obesity, and hypertension,230 which itself can upregulate AR signaling in PCa.225, 231, 232. This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.