The critical role of IL-17A and TH17 cells in experimental crescentic glomerulonephritis was first shown in experimental models of glomerulonephritis, using mice with IL-23 p19, IL-17A, IL-17F, IL-17C and RORγt gene deficiency that all show impaired TH17 immune responses. This evidence concerns the gene IL17A and crescentic glomerulonephritis.