It was shown that CXCR3-deficient mice were partly protected from immune-mediated injury in both the nephrotoxic nephritis (NTN) model of crescentic glomerulonephritis and the MRL-Faslpr model of murine lupus nephritis (Menke et al. 2008; Panzer et al. 2007; Steinmetz et al. 2009). Here, CXCR3 is linked to lupus nephritis.