ENO2 and idiopathic pulmonary arterial hypertension: In the GSEA analysis, the citrate cycle (TCA cycle) (hsa00020, NSE = −1.83, normal P-value = 0.004, FDR = 0.108) and starch and sucrose metabolism (hsa00500, NSE = −1.66, normal P-value = 0.004, FDR = 0.204) were remarkably suppressed in patients with IPAH (Figures 3C,D).