Moreover, according to the results of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, the risk of CV death was higher in the intensified treatment group than in the conventional treatment group, which may be explained by the use of insulin in the intensified treatment group at a higher rate (79 vs. 62%, p < 0.001) and dose (0.41 vs. 0.30 units/kg/day, p < 0.001) than in the standard treatment group (27). This evidence concerns the gene INS and diabetes mellitus.