Intriguingly, after further adjustment for Fins and 2h Pins (Model 5), significant association was still observed between insulin therapy and the presence of carotid plaque in both women (Model 5: OR: 1.810, 95% CI: 1.155–2.837, p =0.010) and men (Model 5: OR: 1.867, 95% CI: 1.307–2.666, p = 0.001) with type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.