ALMS1 protein plays a wide range of biological roles, encompassing both ciliary and extraciliary functions, what has raised some controversy about ALMS should be considered a ciliopathy caused by cilia dysfunction or if, however, it is associated with a loss of ALMS1 functions unrelated to primary cilia (Chen et al., 2017; Hearn, 2019). Here, ALMS1 is linked to ciliopathy.