Interestingly, cardiac anomalies and multiorgan fibrosis, common phenotypes related to ALMS, are well-known to be associated with aberrant transforming growth factor beta/bone morphogenetic protein (TGF-β/BMP) signaling (reviewed in Heger et al., 2016; Walton et al., 2017). This evidence concerns the gene TGFB1 and Alstrom syndrome.