PATZ1 and cancer: PATZ1 regulates a plethora of cellular processes including spermatogenesis (Fedele et al., 2008); senescence (Cho et al., 2012); embryonic stem cell pluripotency and reprogramming (Ma et al., 2014a, b; Ow et al., 2014); T-cell development, as well as cancer development (Bilic et al., 2006; Sakaguchi et al., 2010; Abramova et al., 2013; Sakaguchi et al., 2015).