SP100 and cytomegalovirus infection: In turn, Sp100 depletion favors IE1 expression (Kim et al., 2011; Ashley et al., 2017); individual depletion of PML, Sp100 or Daxx showed that each factor was restrictive on its own (Ashley et al., 2017), combined depletion of Sp100/PML or Sp100/Daxx further enhanced HCMV gene expression initiation (Adler et al., 2011), and combined depletion of all PML/Sp100/Daxx were more permissive to HCMV infection (Ashley et al., 2017), resembling the above discussed intrinsic immunity factor’s dynamics against HSV1.