Evidence suggests these processes may be regulated, at least in part, by the microphthalmia/transcription factor E (MiT/TFE) family of transcription factors (MITF, TFE3, TFEB, and TFEC), which control transcriptional programs for autophagy and lysosome biogenesis to sustain cancer cell growth and survival under stress conditions (74). Here, MITF is linked to cancer.