Shen et al. (148) found that METTL3 can directly interacts with the 5’/3’UTR regions of Hexokinase 2 (HK2) mRNA and the 3’UTR region of Glucose transporter type 1 (GLUT1, also SLC2A1) mRNA, and subsequently stabilized their mRNAs and activated the glycolysis pathway in CRC cells in a IGF2BP2- or IGF2BP2/3-dependent manner. The gene discussed is HK2; the disease is colorectal carcinoma.