Overexpression of the rs8100241[A] allele significantly increased the ANKLE1 m6A level that was catalyzed by writers METTL3/14 and WTAP and recognized by reader of YTHDF1, thus the dysregulated ANKLE1 protein is facilitated compared to that of rs8100241[G] allele, which is significantly related to susceptibility of CRC. This evidence concerns the gene METTL3 and colorectal carcinoma.