In addition, upregulated METTL3 could facilitate CRC cell proliferation, progression, and metastasis by various signaling pathways including miR-1246/SPRED2/MAPK signaling pathway, p38/ERK pathway, and cyclin E1 (CCNE1) cell proliferation pathway (147, 149, 150). Here, CCNE1 is linked to colorectal carcinoma.