TMPRSS2 and prostate adenocarcinoma: Some other research found that molecular events of T-NEPC such as TMPRSS2-ERG gene rearrangement and fusion genes were similar to prostate adenocarcinoma, suggested that T-NEPC originated from prostate adenocarcinoma and ADT enabled adenocarcinoma cells to develop into T-NEPC cells through the mechanism of adaptive response/tumor resistance (9, 10).