In unadjusted Cox regressions, an excess risk of overall death was observed in tumors with negative PSA (HR = 2.86; 95% CI = 1.39–6.73) and tumors with small-cell carcinoma (HR = 4.35; 95% CI = 1.76–7.36) (Table 3). This evidence concerns the gene KLK3 and small cell carcinoma.