Prostate adenocarcinoma with focal increased neuroendocrine differentiation (Figures 2A–F), confirmed by immunohistochemistry with neuroendocrine differentiation, but did not meet the criteria of group 3, of which 23 cases were matched, all 23 cases were AR positive, and 17 cases were PSA positive. Here, KLK3 is linked to prostate adenocarcinoma.