Effects of bioactive compounds such as monacolin K, naringin, tocopherol in this combination of selected functional food mixture (MSFF) may exert curative action on hypercholesterolemia via inhibition of lipid peroxidation, HMGCoA reductase and ACAT2 activities compared to the treatment using single ingredient. The gene discussed is ACAT2; the disease is Hypercholesterolemia.