Similarly, downregulating inflammation degree‐related proteins such as haptoglobin, complement component 3, myeloperoxidase, Annexin A2, heat shock protein family A member 4, and heterogeneous nuclear ribonucleoprotein U (Hnrpu), a protein biomarker for colorectal carcinoma, may also assist in improving DSS‐induced inflammation (Lyu et al., 2017). This evidence concerns the gene ANXA2 and colorectal carcinoma.