In this study, we found that the administration with different dosages of SFN was able to increase serum insulin level, enhance HOMA‐β index, decrease fasting blood glucose and serum total cholesterol, triglyceride, low‐density lipoprotein (LDL‐C), fibroblast growth factor21 (FGF21) levels, ease NAFLD level, and repair the pancreas tissue. This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.