In this study, we found that the administration with different dosages of SFN was able to increase serum insulin level, enhance HOMA‐β index, decrease fasting blood glucose and serum total cholesterol, triglyceride, low‐density lipoprotein (LDL‐C), fibroblast growth factor21 (FGF21) levels, ease NAFLD level, and repair the pancreas tissue. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.