CD274 and neoplasm: For example, exosomal PD‐L1 inhibit CD8+ T cells activation associated with anti‐PD1‐PD‐L1 therapy (Chen et al., 2018; Poggio et al., 2019; Ricklefs et al., 2018), and, if exosomal PD‐L1 is suppressed, systemic anti‐tumour immunity and memory will be recovered (Poggio et al., 2019; Ricklefs et al., 2018).