Notably, all six expression-based markers for human TI-Tregs, TIGIT, TNFRSF9, ICOS, CCR8, CD83, and CCRL2, were ranked within the top 10%, which indicates that they are likely to play major roles in tumor-associated Treg functions (Fig. 3d, Table S4-5). The gene discussed is ICOS; the disease is neoplasm.