COL11A1 and colorectal cancer: The COL11A1 gene mutation was analyzed on COSMIC database comprising more than 2406 samples of colorectal cancer out of which 249 were recorded for mutations, among them the missense substitution is highest with 51.81% followed by synonymous substitution (15.66%), frameshift mutation (15.66%), nonsense substitution (4.42%) and other types (4.02%) (Figure 5A).