Studies on left-sided and right-sided colon cancer, it has been found that COL11A1, TWIST1, insulin-like 5, and chromogranin A were upregulated across the right-sided colon cancer more significantly than that of the left-sided cancer, with a sharp downregulation in 3β-hydroxysteroid dehydrogenase protein (Su et al., 2019). Here, INSL5 is linked to malignant colon neoplasm.