JQ1 is a small molecule that binds competitively to bromodomains and inhibits MYC gene transcription by displacing bromodomain 4 (BRD4) (156), and has the added benefit of reducing PD-L1 expression by tumor cells and APCs (157) while also directly promoting T cell persistence and effector functions in the TME (157, 158). This evidence concerns the gene CD274 and neoplasm.