ERBB2 and neuroblastoma: Human epidermal growth factor receptor 2 (HER2; also known as c-erbB-2, due to the encoding gene, or HER2/neu, due to its discovery in neuroblastoma rat models (51)), is an epithelial growth factor oncoprotein, localized in the cell membrane and involved in communication among cells for proliferation, differentiation and survival signalling (2).