In FLS from subjects with RA, as in those from non-inflamed subjects, adiponectin significantly induced the production of CXCL8, CXCL1, CXCL10, and IL-6, and the patterns of CCL5, CXCL5, CCL2, and CCL11 stimulation were also similar to those in FLS from non-inflamed subjects (Supplementary Figure 4). This evidence concerns the gene CXCL8 and rheumatoid arthritis.