CD8A and colorectal cancer: Evidence for a similar involvement of NR4A in human exhausted CD8+ T cells came from a study of TILs in colorectal cancer where Nr4a1 transcription and NBRE motif in transcriptionally active hypomethylated DNA regions were enriched in Ag-specific CD8+ TILs (CD39+CD103+) compared to bystander TILs (CD39−CD103+ or CD39−CD103−) (98).