Some studies have demonstrated the inhibitory effects of simvastatin and Y-27632 on TGF-β-induced myofibroblast differentiation from fibroblasts derived from different disease specimens, such as nasal polyps (24), keloids (20), and penile tunica albuginea from Peyronie’s disease (21). The gene discussed is TGFB1; the disease is Abnormality of connective tissue.