Pharmacological blockade of CPT1 for example resulted in severe hepatic steatosis in fasted mice (46), while mice that lack peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor controlling expression of almost all FAO genes, also develop hepatic steatosis along with high plasma FFA concentrations, hypoglycemia and hypoketonemia when fasted (47, 48). This evidence concerns the gene CPT2 and Hepatic steatosis.