PPARA and Hepatic steatosis: Pharmacological blockade of CPT1 for example resulted in severe hepatic steatosis in fasted mice (46), while mice that lack peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor controlling expression of almost all FAO genes, also develop hepatic steatosis along with high plasma FFA concentrations, hypoglycemia and hypoketonemia when fasted (47, 48).