Additionally, there are no significant differences in terms of onset of first symptom, frequency of family history of dementia as well as the other traditional cardiovascular risk factors of hypertension, hyperlipidemia, diabetes mellitus and cigarette smoking between VCI-SVD patients with pathogenic NOTCH3 variants and VCI-SVD patients without identified variants. This evidence concerns the gene NOTCH3 and snowflake vitreoretinal degeneration.