Furthermore, lower serum irisin concentrations are also found in children with metabolic syndrome, and the irisin concentrations are negatively correlated with biomarkers of endothelial inflammation and dysfunction, such as ICAM-2 and vascular cell adhesion molecule-1 (VCAM-1; Huerta-Delgado et al., 2020). This evidence concerns the gene VCAM1 and metabolic syndrome.