Recently, both in vivo and in vitro studies have revealed that optic atrophy 1 (Opa1) expression is downregulated in infarcted heart, whereas irisin treatment upregulated the expression of Opa1 and protects cardiomyocytes from further damage following MI (Xin and Lu, 2020). The gene discussed is FNDC5; the disease is myocardial infarction.