CD4+ Tm (CD4+ CD45RBhigh) cells isolated from the lamina propria of mice with colitis were cultured in vitro for 8 weeks and transplanted into SCID mice to cause acute colitis, and CD4+CD44+CD62L− memory T cells were found to overaggregate in the lamina propria of the colon (Takahara et al., 2013). Here, CD4 is linked to colitis.