After the mice with colitis were treated with curcumin and mesalazine, the number of TEM cells (Figures 4C1–5) was significantly higher than that in mice with untreated colitis, while the number of CD4+ TEM (Figures 4D1–5) and CD8+ TEM cells (Figures 4E1–5) decreased significantly. The gene discussed is CD8A; the disease is colitis.