Activation of ALDH2 by Alda-1 restores ALDH2 activity and attenuates oxidative stress-induced injury in various animal models of atherosclerosis, Parkinson’s disease, ischemia/reperfusion injury, heart failure, and stroke (Chen et al., 2014; Fu et al., 2014; Breitzig et al., 2016; Lu et al., 2017; Zhang et al., 2018). The gene discussed is ALDH2; the disease is atherosclerosis.