A study proved that AK7 was more specific to SIRT2 compared to SIRT1 and SIRT3 and was found to improved neuronal survival, motor function, reduced brain atrophy, and the levels of aggregated mutant HTT in two genetic mouse models of HD (Taylor et al., 2011; Chopra et al., 2012). Here, SIRT1 is linked to Brain atrophy.