However, specific pharmacological SIRT2 inhibition with AK7 increased non-amylogenic APP processing by α-secretase and reduced processing by BACE1, down-regulating its expression in the hippocampus and ameliorating the AD-associated pathology in 3xTg-AD and APP/PS1 mice (Wang Y. et al., 2020). Here, SIRT2 is linked to Alzheimer disease.