SIRT2 is the major isoform which is expressed highly in brain cells mainly in myelin cells and also in olfactory and hippocampal neurons (Southwood et al., 2007; Pandithage et al., 2008), where it is involved in the suppression of glioma migration, cytoskeletal growth cone dynamics, neurite outgrowth and oligodendrocyte arborization (Harting and Knöll, 2010). Here, SIRT2 is linked to central nervous system cancer.