The in vitro studies performed by Biella G et al. suggested that inhibition of SIRT2 by AGK2 and AK7 reduced the Aβ production in H4-SW neuroglioma cells and modified the APP proteolytic processing, leading to a reduction of soluble Aβ and an increase of soluble α-amyloid protein in two AD transgenic mouse models (3xTg-AD and APP23). Here, SIRT2 is linked to Alzheimer disease.