Oligomeric Aβ induces glycogen synthase kinase-3beta (GSK-3β) expression in the brains of AD patients; this results in tau hyperphosphorylation and microtubule disruption originating the neurofibrillary tangles, impairment of memory and long-term potentiation (LTP), and neuronal apoptosis (DaRocha-Souto et al., 2012). Here, MAPT is linked to Alzheimer disease.