CREB1 and Huntington disease: One of the mechanisms of action of SIRT1 is the deacetylation and activation of TORC1 (CREB regulated transcription coactivator1), accompanied by its binding with CREB to transcribe BDNF, a neuroprotective factor in HD (Jeong et al., 2012; Zuccato and Cattaneo, 2007).