Second, the dosage of daprodustat in our study varied, and several phase-II studies have demonstrated that daprodustat exerts a dose-response effect on Hb levels, and a number of iron metabolism indices in both NDD and DD patients (Brigandi et al., 2016; Holdstock et al., 2016; Akizawa et al., 2017; Bailey et al., 2019). The gene discussed is GSTM1; the disease is dentin dysplasia.