Consistent with the previous report, we found the phosphorylation of PKC/MEK/ERK was significantly increased in the lesioned striatum of the PD+saline+L-dopa group as compared to the PD group (#p < 0.05, ##p < 0.01 vs. sham, Figure 5, n = 4/group). This evidence concerns the gene MAP2K7 and Parkinson disease.