GRIN2B and Parkinson disease: Our data indicated that systemic inflammation, by exacerbating neuroinflammation and facilitating the NR2B subunit activity, increased the susceptibility to LID in 6-OHDA lesioned rats, suggesting a possible pathophysiological role of the systemic inflammatory response in the appearance of dyskinesia, at least in the 6-OHDA-lesioned rat model of PD.