NOS1 and Parkinson disease: In addition, several previous studies demonstrated that neuronal proinflammatory factors have been found to correlate with the LID expression in the 6-OHDA rat models of PD, where the development of AIM was accompanied by an increased immunoreactivity for the microglial marker OX-42, together with GFAP and with increases of nNOS, cyclooxygenase-2 (COX2), and NF-κB levels in the striatum (Bortolanza et al., 2015a,b; Dos-Santos-Pereira et al., 2016).