The role described here for PGC-1α in modulating GABARα2 expression and GABAergic neurotransmission may be important for brain disorders characterized by GABAergic dysfunctions (Lewis et al., 2008; Ramamoorthi and Lin, 2011; McMeekin et al., 2016; Engin et al., 2018). This evidence concerns the gene PPARGC1A and brain disorder.