KCNH2 and epilepsy: KCNH2 encodes the α subunit for Kv11.1 potassium channel, and KCNH2 mutations cause type 2 long QT syndrome that typically presents with a seizure disorder or epilepsy (Omichi et al., 2010); however, whether the seizure or epilepsy is neurally mediated or due to a ventricular arrhythmia remains controversial (Johnson et al., 2009).