Among the 89 lncRNAs expressed from de novo epigenomically activated regions in MM, we identified LINC00582 (ENSG00000229228, named SMILO) (Fig. 3A), and intergenic lncRNA composed of two exons, located between TSNAX and DISC1 coding genes, and transcribed from the negative strand of chromosome band 1q42.2, a genomic region frequently amplified in MM patients. The gene discussed is DISC1; the disease is Miyoshi myopathy.