PDCD1 and Miyoshi myopathy: These exhaustion markers included TIGIT, a recently described protein that plays a role in the immune escape in MM [39–41], PD-1, and LAG-3 but neither CTLA-4 nor TIM-3 (p = 0.0002, p = 0.0004, p = 0.0229, p = 0.25, and p = 0.8, respectively, Fig. 1e).