Particularly promising in this respect is the demonstration of strong associations of both schizophrenia and bipolar disorder with genetic variations in voltage-gated calcium channels (VGCCs) [3], especially the CACNA1C gene, which encodes the pore-forming α1C subunit of CaV1.2 L-type VGCCs (L-VGCCs) [4, 5]. The gene discussed is CACNA1C; the disease is bipolar disorder.