Additionally, enrichment of the KEGG Cytokine-Cytokine Receptor Interaction gene signature was observed in samples from dexamethasone-resistant ALL patients (Fig. 5d), which is in line with the observation that SOCS2 expression is downregulated as SOCS family members act as negative regulators of cytokine receptor signaling40. Here, SOCS2 is linked to acute lymphoblastic leukemia.