Additional File: Supplementary Table 2 showed that plasma OPN are reasonably good at discriminating dementia, namely AD without CeVD (AUC = 0.80, sensitivity = 72.5%, specificity = 85%), AD with CeVD (AUC = 0.71, sensitivity = 58%, specificity = 82.5%) and VaD (AUC = 0.73, sensitivity = 64.5%, specificity = 83.8%) from NCI controls. The gene discussed is SPP1; the disease is Alzheimer disease.