Table 4 shows that every tenfold increase in OPN levels was significantly associated with increases in cortical infarct count (RR = 10.72; 95% CI 3.11 to 36.93), lacune count (RR = 4.27; 95% CI = 1.96 to 9.28) and ARWMC scores (MD = 5.21; 95% CI = 2.44 to 7.99). This evidence concerns the gene SPP1 and infarction.