On the other hand, Table 5 shows that every tenfold increase in OPN levels were also associated with all three neuroimaging markers of brain atrophy, namely central atrophy (OR = 18.00; 95% CI 3.86 to 84.05), cortical atrophy (OR = 22.67; 95% CI 3.65 to 140.82) and medial temporal atrophy (OR = 55.96; 95% CI 9.51 to 329.32). This evidence concerns the gene SPP1 and Brain atrophy.