SPP1 and Alzheimer disease: As seen in Additional File: Supplementary Table 3, plasma OPN has potentially good diagnostic value after adjusting for multiple covariates, in particular for AD without CeVD (AUC = 0.78, sensitivity = 92.3%, specificity = 59.7%), AD with CeVD (AUC = 0.79, sensitivity = 81%, specificity = 69.9%) and VaD (AUC = 0.81, sensitivity = 95.7%, specificity = 63.1%).