However, high expressions of other reprogramming factors Myc, Klf4, and Nanog44 were observed in spheres compared with conventional adherent cells (Fig. S8a), but this was not enhanced by MYD88 constructs in the spheres (Fig. 6f), suggesting OCT3/4 is an effector molecule of the MYD88-HIF-1-mediated generation of cancer stem cell-like cells. This evidence concerns the gene HIF1A and cancer.