To elucidate the role of MYD88 in tumour development, we generated retroviral vectors expressing murine Myd88 cDNA constructs including wild type (WT) and constitutively active forms of MYD88, a truncated form containing a death domain (DD)31 and a point mutant (L265P) corresponding to the human L265P mutation, which was identified as a gain-of-function driver mutation of human lymphoma19. This evidence concerns the gene MYD88 and neoplasm.