GJB2 and hearing loss disorder: These three genes are known to have hotspot variants causing non-syndromic hearing loss in Asian populations, including c.109G>A, c.235delC, and c.299_300delAT in GJB2, c.919-2A>G, c.1229C>T, and c.2168A>G in SLC26A4, and m.1555A>G in MT-RNR120–22.