There were significant differences in parameters, including age, BMI, waist circumference, blood pressure, blood urea nitrogen, creatinine, estimated glomerular filtration rate (eGFR), uric acid, triglycerides, insulin, homeostasis model assessment of insulin resistance (HOMA-R), hemoglobin A1c, brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hsCRP), in both male and female subjects. Here, NPPB is linked to Insulin resistance.