In recent studies on breast cancer, a CNN trained on tissue histomorphology predicted the steroid hormone receptor status, expression of the Ki-67 protein (indicator of cell proliferation), human epidermal growth factor receptor 2 (ERBB2, alias HER2; HGNC:3430) and a series of other tissue biomarkers in a large proportion of the patients11,12. This evidence concerns the gene ERBB2 and breast carcinoma.