Interestingly, some of the autoantigens that were not found in AIRE+ cells (CYP21A2, CYP17A1, CYP11A1) are often targeted by autoantibodies in thymoma patients but do not correlate with AIRE expression in thymoma samples, implying that they are not AIRE-dependent genes87,88. The gene discussed is CYP17A1; the disease is thymoma.