For example, the overproduction of fibroblast growth factor 2 (FGF-2)15–18, granulocyte colony-stimulating factor (G-CSF)19, granulocyte-macrophage colony-stimulating factor (GM-CSF)20, and fractalkine (CX3CL1)21 have been found to participate in immune-related inflammatory disease (e.g., rheumatoid arthritis, autoimmune gastritis, and Crohn’s disease). Here, CSF2 is linked to Crohn disease.