IFITM1 overexpression decreased p21 transcription and contributed to breast cancer progression.40 Meanwhile, some studies indicated that IFITM1 played a key role in the radio-resistance of oral neoplasm through the pSTAT3/p-p21 pathway.41 PLEKHM3 could potentially function as a scaffold protein for PKB during differentiation through PI3K signaling cascade.42 In the current study, we found that miR-320 inhibited IFITM1 expression in CFs and target PLEKHM3 in CMs, which was involved in the process of cardiac remodeling. This evidence concerns the gene PLEKHM3 and breast cancer.