In line with our study, previous study also demonstrated different regulation patterns of various TFs among CMs, CFs, ECs and macrophages during HF.26 While we are still pursuing to determine whether Ang II regulates these cell-type-specific TFs through transcriptional, translational or post-translational manner, the existing data provided evidence that a cluster of cell-type-specific TFs were responsible for the different destinations of Ago2 in CMs and CFs under stress. Here, AGO2 is linked to hydrops fetalis.