APP and Mental deterioration: No acceleration in cognitive decline after a ZD diet was observed at either age in the Y-maze task (three-way interaction: χ2(7) = 7.34, p = 0.394) or Morris water maze task (interaction term: F(1) = 0.284, p = 0.570), indicating that the effect of zinc deficiency seen in the APP/PS1 mice was specific to amyloidopathy and its downstream effects (Fig. 3D,E).