APP and Zinc deficiency: Severe zinc deficiency can lead to weight loss, but the marginal ZD diet used here had no effect on body weight compared with normal diet (Fig. 2D) (diet main effect: F(2,43) = 0.49, p = 0.616) or fat mass (data not shown, diet main effect: F(2,74) = 0.14, p = 0.866) of the WT or APP/PS1 mice.